Inclusion Criteria:

1. * Males or females of non-childbearing potential, between 18 and 55 years of age
2. * In good health, determined by no clinically significant findings from medical history, 12-lead electrocardiogram (ECG), vital signs, and clinical laboratory assessments
3. * Body mass index (BMI) 18 to 32 kg/m\^2 (inclusive)
4. * Cohorts 1 and 2 ethnicity requirements: none
5. * Cohort 3 ethnicity requirements: first- or second-generation Japanese participants

Exclusion Criteria:

1. * Significant history of any hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, immunologic, musculoskeletal disease, or allergic disease (as determined by the Investigator)
2. * Any ocular condition likely to increase the risk of eye toxicity
3. * Gastrointestinal disorders that will affect oral administration or absorption of TYRA-300-B01
4. * Females of child-bearing potential and males who plan to father a child while enrolled in this study