Inclusion Criteria:

1. Histologic confirmation of carcinoma of the prostate without small cell features
2. Documented prostate cancer progression by Prostate Cancer Working Group 3 (PCWG3) criteria while castrate
3. Evidence of metastatic disease documented by either bone lesions on radionuclide bone scan and/or soft tissue lesions on computed tomography (CT)/magnetic resonance imaging (MRI)
4. Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1
5. Ongoing androgen deprivation therapy (ADT) with a gonadotropin-releasing hormone (GnRH) agonist/antagonist or bilateral orchiectomy (i.e., surgical or medical castration) confirmed by testosterone level ≤ 1.73 nmol/L (50 ng/dL) at the screening visit
6. Chemotherapy-naive for metastatic castration-resistant prostate cancer (mCRPC) and have received at least one novel antiandrogen therapy (NAT)

Exclusion Criteria:

1. Concurrent malignancy (present during screening) requiring treatment or history of prior malignancy active within 2 years prior to treatment assignment in Part 1 or randomization in Part 2
2. Untreated central nervous system (CNS) metastases
3. Leptomeningeal metastases
4. Active, known or suspected autoimmune disease

Other protocol-defined inclusion/exclusion criteria apply